There will be a lot of world-class players locking horns against each other in the round of 16 match but the spotlight will be on two undoubted global footballing icons - Cristiano Ronaldo and Luis Suarez.
The European champions will face Uruguay in Sochi for a place in the quarter-finals after finishing as runners-up behind Spain in Group B.
"These are different circumstance of course, the hosts have huge support and they've had a very good tournament, while Uruguay has high quality and top-notch players and they're all excellent - but Portugal too".
And after 12 years in charge of the team, Tabarez believes Uruguay are a contender to win the competition. Clearly, the momentum will be with the South American team and they will be a force to reckon with in the upcoming tie.
Under him they have won a Copa America and reached the semi-finals of the World Cup in 2010.
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However, Douglas Costa will miss the game, having suffered a thigh injury after coming off the bench against Costa Rica . Former Brazil global Sylvinho admits that he was "worried" about Neymar before the World Cup began.
This will be the third encounter between Portugal and Uruguay and the first one in a World Cup.
That was just one league goal fewer than Ronaldo.
2-time former World Cup winners Uruguay started off their campaign with hard earned 1-0 victory Egypt courtesy of 89th-minute victor by Jose Gimenez. Meanwhile, three of Portugal's last four goals have come from outside the box.
Cristiano Ronaldo can equal the record as the player with the most appearances at the World Cups and European Championships if he plays in Portugal's next match against Uruguay while Ronaldo is yet to score a goal in 424 minutes for Portugal in the knockout stages of the World Cup.
Uruguay are hopeful Jose Maria Gimenez will return from injury to resume his centre-back partnership with Atletico Madrid team-mate Diego Godin.
"We have to play as a team". "I hope my team can be as strong as Uruguay, and that Cristiano can then make the difference".