The games between the Yankees and Red Sox in London next season will mark the first Major League Baseball regular-season contests to ever be played in Europe.
Major League Baseball also confirmed it is committed to playing in London in 2020 as it tries to "establish a long-term footprint in the city".
The NFL have been playing regular-season games in London since 2007, and could eventually host a franchise if the proposed purchase of Wembley Stadium by Shahid Khan, the owner of Jacksonville Jaguars, goes ahead.
"Because this is our first foray into Europe, it's really important that we make as big a splash as possible", MLB Commissioner Rob Manfred told a news conference in London.
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It has already been announced that Oakland and Seattle will play next season's opener at the Tokyo Dome on March 20-21.
"Major League Baseball is excited to be bringing one of the most storied rivalries in sports to the passionate fans of London", said commissioner Robert D. Manfred Jr. "In future years there may be many more games in London and maybe a baseball team permanently".
Red Sox principal owner John Henry, who also owns Liverpool FC of the Premier League, said that Boston and NY have been talking about playing overseas for some time.
Yankees right fielder Aaron Judge puts Red Sox relief pitcher Joe Kelly in a headlock after Kelly hit Yankees' Tyler Austin with a pitch.
"I can't wait to hear someone shout "play ball" at London Stadium".
It's the first time since 2002 Boston and NY have met with the two best records in all of baseball.